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Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration

30 Mar 2021

Abstract excerpt

In the first trimester of human pregnancy, low oxygen tension or hypoxia is essential for proper placentation and placenta function. Low oxygen levels and activation of signaling pathways have been implicated as critical mediators in the promotion of trophoblast differentiation, migration, and invasion with inappropriate changes in oxygen tension and aberrant Notch signaling both individually reported as...

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PMID: 33784241
DOI: 10.1530/rep-20-0483

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