Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy

Abstract excerpt

During human pregnancy, a certain proportion of endothelial cells in uterine spiral arteries are replaced by placental extravillous trophoblasts (EVTs). This process is a pivotal step in spiral artery remodeling (SAR), ensuring the adequate supply of oxygen and nutrients to the fetus. Given the ethical constraints and the lack of suitable in vivo animal models, developing ideal in vitro models is crucial for...