Article

Single-cell sequencing of trophoblasts in preeclampsia and chemical hypoxia in BeWo b30 cells reveals EBI3, COL17A1, miR-27a-5p and miR-193b-5p as hypoxia-response markers

2025-10-01

Abstract excerpt

<h4>Background</h4> Preeclampsia (PE) complicates 2–8% of pregnancies and is marked by placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Integrating patient tissue analyses with experimental models may reveal common molecular markers of trophoblast hypoxic response. <h4>Methods</h4> We analyzed scRNA-seq data from 10 eoPE, 7 late-onset PE (loPE), and corresponding control placent...

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Literature Corpus work: f10b7bb6-158e-56d4-b2ef-50240cf5e77f
DOI: 10.1101/2025.09.30.679431

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