Article

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsia

2026-07-22

Abstract excerpt

Preeclampsia is a major pregnancy complication driven by placental dysfunction, yet research is limited by reliance on patient-derived tissues and models that do not fully capture human disease. Here, we develop a genetically engineered human trophoblast organoid model of preeclampsia that can be generated without access to placental tissue. Using a CRISPR-based Prime Integrase strategy, we engineered induced trop...

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Literature Corpus work: 141b0dca-8a1c-52c8-905f-66fd999f38ef
DOI: 10.64898/2026.07.22.739976

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