Article
Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult.
Cells - 11 Jun 2022
Fuenzalida Barbara, Kallol Sampada, Zaugg Jonas, Mueller Martin, Mistry Hiten D, Gutierrez Jaime, Leiva Andrea, Albrecht Christiane
Abstract excerpt
Preeclampsia (PE) is a pregnancy-specific disorder that affects 3 to 5% of pregnancies worldwide and is one of the leading causes of maternal and fetal morbidity and mortality. Nevertheless, how these events occur remains unclear. We hypothesized that the induction of hypoxic conditions in vitro in primary human trophoblast cells would mimic several characteristics of PE found in vivo. We applied and...
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