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Article

Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

2025-05-06

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage fate. We observed high expression of Chi3l1 in both KCs a...

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Identifiers and source

Literature Corpus work
4834a678-4c19-5672-8195-7093ccaea98d
DOI
10.1101/2025.05.06.652369
Open publication

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Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLDDOI 10.1101/2025.05.06.652369
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