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Article

The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish.

The Journal of biological chemistry - 3 Aug 2018

Zou Qingliang, Gang Kai, Yang Qifen, Liu Xiaolin, Tang Xuemei, Lu Huiqiang, He Jianbo, Luo Lingfei

Abstract excerpt

Degenerative diseases of organs lead to their impaired function. The cellular and molecular mechanisms underlying organ degeneration are therefore of great research and clinical interest but are currently incompletely characterized. Here, using a forward-genetic screen for genes regulating liver development and function in zebrafish, we identified a cq5 mutant that exhibited a liver-degeneration phenotype at 5...

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Identifiers

PMID: 29871925
DOI: 10.1074/jbc.M117.802975
PMCID: PMC6078438

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