Article

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

2023-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Intestinal immune responses to commensals and pathogens are controlled by IL-10 to avoid intestinal immune pathology. We show that the transcription factors Blimp-1 (Prdm-1) and c-Maf are co-dominant regulators of Il10 in Foxp3 + regulatory T cells, but also negatively regulate proinflammatory cytokines in effector T cells. Mice with T cell-specific deletion of Prdm-1, Maf or the combination...

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Literature Corpus work: 233a7861-6bfc-59c1-806f-1d8605884d61
DOI: 10.1101/2023.09.14.557705

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