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Article

Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant.

Psychopharmacology - 1 Apr 2021

O'Reilly Kally C, Connor Michelle, Pierson Jamie, Shuffrey Lauren C, Blakely Randy D, Ahmari Susanne E, Veenstra-VanderWeele Jeremy

Abstract excerpt

RATIONALE: Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is associated with repetitive behaviors seen in both disorders. Chronic blockade of serotonin...

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Identifiers

PMID: 33511450
DOI: 10.1007/s00213-020-05758-8
PMCID: PMC8728944

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