Article

Functional interrogation of a depression-related serotonergic SNP, rs6295, using a humanized mouse model

2018-11-17

Abstract excerpt

The serotonin 1A receptor (5-HT1A) system has been extensively implicated in modulating mood and behavior. Notably, 5-HT1A levels in humans display remarkable variation and differences in receptor levels have been linked with a variety of psychiatric disorders. Further, manipulation of receptor levels in mice suggests that changes in receptor levels that model existing human variation are sufficient to drive behav...

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Literature Corpus work: 9e4fab63-2c87-55a4-bc89-4f3339b62916
DOI: 10.1101/472621

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