Article
Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2017
Muller Christopher L, Anacker Allison Mj, Rogers Tiffany D, Goeden Nick, Keller Elizabeth H, Forsberg C Gunnar, Kerr Travis M, Wender Carly LA, Anderson George M, Stanwood Gregg D, Blakely Randy D, Bonnin Alexandre, Veenstra-VanderWeele Jeremy
Abstract excerpt
Biomarker, neuroimaging, and genetic findings implicate the serotonin transporter (SERT) in autism spectrum disorder (ASD). Previously, we found that adult male mice expressing the autism-associated SERT Ala56 variant have altered central serotonin (5-HT) system function, as well as elevated peripheral blood 5-HT levels. Early in gestation, before midbrain 5-HT projections have reached the cortex, peripheral...
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