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Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats.

BMC genetics - 7 May 2010

Homberg Judith, Nijman Isaäc J, Kuijpers Sylvia, Cuppen Edwin

Abstract excerpt

BACKGROUND: Genetic variation in the regulatory region of the human serotonin transporter gene (SLC6A4) has been shown to affect brain functionality and personality. However, large heterogeneity in its biological effects is observed, which is at least partially due to genetic modifiers. To gain insight into serotonin transporter (SERT)-specific genetic modifiers, we studied an intercross between the Wistar...

Topics

Animals
Behavior, Animal
Crosses, Genetic
Gene Knockout Techniques
Phenotype
Quantitative Trait Loci
Rats
Rats, Inbred BN
Rats, Wistar
Serotonin Plasma Membrane Transport Proteins
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20459657
DOI: 10.1186/1471-2156-11-37
PMCID: PMC2874760

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