Article

Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy

2021-02-23

Abstract excerpt

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety and hyperactivity. Despite their availability, so far advances in drug development have not yielded new treatments. Therefore, testing novel drugs that can ameliorate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1784a157-4f86-53f3-a9bb-a0f1f9bee312
DOI: 10.21203/rs.3.rs-189177/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor OccupancyDOI 10.21203/rs.3.rs-189177/v1Read

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy.Semantic proximity Read

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.Semantic proximity Read

Vorinostat corrects cognitive and non-cognitive symptoms in a mouse model of fragile X syndromeSemantic proximity Read

Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum Disorder.Semantic proximity Read

The selective 5-HT <sub>1A</sub> receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndromeSemantic proximity Read

The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome.Semantic proximity Read

The selective 5-HT1A receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of fragile X syndrome.Semantic proximity Read

Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndromeSemantic proximity Read

The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.Semantic proximity Read

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.Semantic proximity Read

Advances in the treatment of fragile X syndrome.Semantic proximity Read

Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 KO miceSemantic proximity Read