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Article

Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism.

Neuropharmacology - 1 Oct 2023

Higuchi Yuki, Tada Tomoaki, Nakachi Taiga, Arakawa Hiroyuki

Abstract excerpt

The inbred mouse strain, BTBR T+Itpr3tf/J (BTBR), possesses neuronal and circuit abnormalities that underlie atypical behavioral profiles resembling the major symptoms of human autism spectrum disorder (ASD). Forebrain serotonin (5-HT) transmission has been implicated in ASD-related behavioral alterations. In this study, we assessed 5-HT signals and the functional responsiveness in BTBR mice compared to standard...

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Identifiers

PMID: 37301467
DOI: 10.1016/j.neuropharm.2023.109634

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