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Article

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals.

Archives of toxicology - 1 Mar 2021

Marchetti Francesco, Zhou Gu, LeBlanc Danielle, White Paul A, Williams Andrew, Yauk Carole L, Douglas George R

Abstract excerpt

The Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is optimized for rapidly proliferating tissues such as bone marrow (BM). A sampling time of 28 days (28 + 28d) is...

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Identifiers

PMID: 33506374
DOI: 10.1007/s00204-021-02977-6
PMCID: PMC7904718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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