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Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2018

Marchetti Francesco, Aardema Marilyn, Beevers Carol, van Benthem Jan, Douglas George R, Godschalk Roger, Yauk Carole L, Young Robert, Williams Andrew

Abstract excerpt

The Organisation for Economic Co-operation and Development Test Guideline (TG) 488 for the transgenic rodent (TGR) mutation assay recommends two sampling times for assessing germ cell mutagenicity following the required 28-day exposure period: 28 + > 49 days for mouse sperm and 28 + >70 days for rat sperm from the cauda epididymis, or three days (i.e., 28 + 3d) for germ cells from seminiferous tubules (hereafter,...

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Identifiers

PMID: 30057017
DOI: 10.1016/j.mrgentox.2018.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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