Article
The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene.
Environmental and molecular mutagenesis - 1 Jan 2026
Göpfert Alina, Ronnenberg Kylee Kendra Marie, Ruelker Claudia, Spang Silke, Honarvar Naveed, Landsiedel Robert
Abstract excerpt
Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine-guanine-phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes. The in vitro transgenic rodent assay (TGRA) in primary MutaMouse hepatocytes is a novel approach for the detection and quantification of gene...
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