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In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice.

Environmental health perspectives - 1 Jan 2017

Meier Matthew J, O'Brien Jason M, Beal Marc A, Allan Beverly, Yauk Carole L, Marchetti Francesco

Abstract excerpt

BACKGROUND: Mosaicism, the presence of genetically distinct cell populations within an organism, has emerged as an important contributor to disease. Mutational events occurring during embryonic development can cause mosaicism in any tissue, but the influence of environmental factors on levels of mosaicism is unclear. OBJECTIVES: We investigated whether in utero exposure to the widespread environmental mutagen...

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Identifiers

PMID: 27448386
DOI: 10.1289/EHP211
PMCID: PMC5226697

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Source receipt: pubmed, retrieved 7 Sept 2026.

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