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Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2018

Marchetti Francesco, Aardema Marilyn J, Beevers Carol, van Benthem Jan, Godschalk Roger, Williams Andrew, Yauk Carole L, Young Robert, Douglas George R

Abstract excerpt

The Organisation for Economic Co-operation and Development Test Guideline 488 (TG 488) provides recommendations for assessing germ cell and somatic cell mutagenicity using transgenic rodent (TGR) models. However, important data gaps exist for selecting an optimal approach for simultaneously evaluating mutagenicity in both cell types. It is uncertain whether analysis of germ cells from seminiferous tubules...

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PMID: 30057023
DOI: 10.1016/j.mrgentox.2018.05.021

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TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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