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Article

Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures.

Communications biology - 14 Aug 2020

Beal Marc A, Meier Matthew J, LeBlanc Danielle P, Maurice Clotilde, O'Brien Jason M, Yauk Carole L, Marchetti Francesco

Abstract excerpt

Transgenic rodent (TGR) models use bacterial reporter genes to quantify in vivo mutagenesis. Pairing TGR assays with next-generation sequencing (NGS) enables comprehensive mutation pattern analysis to inform mutational mechanisms. We used this approach to identify 2751 independent lacZ mutations in the bone marrow of MutaMouse animals exposed to four chemical mutagens: benzo[a]pyrene, N-ethyl-N-nitrosourea,...

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Identifiers

PMID: 32796912
DOI: 10.1038/s42003-020-01174-y
PMCID: PMC7429849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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