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Article

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish.

Cells - 22 Jan 2021

Campanari Maria-Letizia, Marian Anca, Ciura Sorana, Kabashi Edor

Abstract excerpt

The "distal axonopathy" hypothesis in amyotrophic lateral sclerosis (ALS) proposes that pathological changes occur at the neuromuscular junction (NMJ) early in the disease. While acetylcholinesterase (AChE) plays an important role in the functionality of the NMJ, its potential role in ALS remains unexplored. Here, we identified AChE as a limiting factor regulating muscle/motor neuron connection in a vertebrate...

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Identifiers

PMID: 33499374
DOI: 10.3390/cells10020221
PMCID: PMC7911940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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