Article
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.
Human molecular genetics - 15 Apr 2013
Diaper Danielle C, Adachi Yoshitsugu, Sutcliffe Ben, Humphrey Dickon M, Elliott Christopher J H, Stepto Alan, Ludlow Zoe N, Vanden Broeck Lies, Callaerts Patrick, Dermaut Bart, Al-Chalabi Ammar, Shaw Christopher E, Robinson Iain M, Hirth Frank
Abstract excerpt
Cytoplasmic accumulation and nuclear clearance of TDP-43 characterize familial and sporadic forms of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, suggesting that either loss or gain of TDP-43 function, or both, cause disease formation. Here we have systematically compared loss- and gain-of-function of Drosophila TDP-43, TAR DNA Binding Protein Homolog (TBPH), in synaptic function and...
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