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Article

Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP‐43 Q331K transgenic mouse model of amyotrophic lateral sclerosis

2 Jan 2018

Abstract excerpt

Transactive response DNA‐binding protein‐43 (TDP‐43) is involved in gene regulation via the control of RNA transcription, splicing, and transport. TDP‐43 is a major protein component of ubiquinated inclusions that are found in amyotrophic lateral sclerosis (ALS); however, the function of TDP‐43 at the neuromuscular junction (NMJ) and its role in ALS pathogenesis is largely unknown. Here, we show that TDP‐43 Q331K...

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PMID: 29295857
DOI: 10.1096/fj.201700835r

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