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Article

TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

3 Jul 2020

Abstract excerpt

BACKGROUND: Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system which is also characterized by aberrant expression of retrotransposable elements (RTEs). Although the TDP-43 function was shown...

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PMID: 32620127
DOI: 10.1186/s12915-020-00816-1

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