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Article

Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jan 2013

Armstrong Gary A B, Drapeau Pierre

Abstract excerpt

TAR DNA binding protein (TDP-43, encoded by the TARDBP gene) has recently been shown to be associated with amyotrophic lateral sclerosis (ALS), but the early pathophysiological deficits causing impairment in motor function are unknown. Here we expressed the wild-type human gene (wtTARDBP) or the ALS mutation G348C (mutTARDBP) in zebrafish larvae and characterized their motor (swimming) activity and the structure...

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Source

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Identifiers

PMID: 23345247
DOI: 10.1523/JNEUROSCI.4003-12.2013
PMCID: PMC6618732

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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