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Article

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

28 Feb 2013

Abstract excerpt

Amyotrophic lateral sclerosis is a devastating, progressive neurodegenerative disease that affects upper and lower motor neurons. Although several genes are identified as the cause of familial cases, the pathogeneses of sporadic forms, which account for 90% of amyotrophic lateral sclerosis, have not been elucidated. Transactive response DNA-binding protein 43 a nuclear protein regulating RNA processing,...

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PMID: 23449777
DOI: 10.1093/brain/awt029

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Loss of TDP-43 causes age-dependent progressive motor neuron degenerationPMID 23449777Read ↗

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