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Article

Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells.

In vivo (Athens, Greece) - 12 Nov 2016

Roolf Catrin, Kretzschmar Christin, Timmer Katrin, Sekora Anett, Knübel Gudrun, Murua Escobar Hugo, Fuellen Georg, Ibrahim Saleh M, Tiedge Markus, Baltrusch Simone, Müller Sarah, Köhling Rüdiger, Junghanss Christian

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) encodes for the respiratory chain proteins. Genetic alterations in mtDNA have been described during aging and linked to impaired hematopoiesis. MATERIALS AND METHODS: We investigated two novel conplastic mouse strains harboring a mitochondrial nt7778 G/T polymorphism leading to an amino acid exchange in respiratory chain complex V. Effects on reactive oxygen species (ROS) and...

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PMID: 27815458
DOI: 10.21873/invivo.10991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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