Article
Mitochondrial mutations alter endurance exercise response and determinants in mice.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2022
Schaefer Patrick M, Rathi Komal, Butic Arrienne, Tan Wendy, Mitchell Katherine, Wallace Douglas C
Abstract excerpt
Primary mitochondrial diseases (PMDs) are a heterogeneous group of metabolic disorders that can be caused by hundreds of mutations in both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) genes. Current therapeutic approaches are limited, although one approach has been exercise training. Endurance exercise is known to improve mitochondrial function in heathy subjects and reduce risk for secondary metabolic...
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