Article

Maternally inherited differences within mitochondrial Complex I control murine healthspan

2018-11-16

Abstract excerpt

Mitochondrial complex I, the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery, has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA-encoded complex I genes and lifespan in humans have bee...

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Literature Corpus work: a4c5c090-aac3-5dac-a311-dd69ebc47927
DOI: 10.1101/472092

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