Article
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival.
Mechanisms of ageing and development - 1 Apr 2021
Dato Serena, Crocco Paolina, De Rango Francesco, Iannone Francesca, Maletta Raffaele, Bruni Amalia C, Saiardi Adolfo, Rose Giuseppina, Passarino Giuseppe
Abstract excerpt
Several studies reported that genetic variants predisposing to neurodegeneration were at higher frequencies in centenarians than in younger controls, suggesting they might favor also longevity. IP6K3 and IPMK regulate many crucial biological functions by mediating synthesis of inositol poly- and pyrophosphates and by acting non-enzymatically via protein-protein interactions. Our previous studies suggested they...
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