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Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.

Biochimica et biophysica acta - 1 Sept 2016

Crocco Paolina, Saiardi Adolfo, Wilson Miranda S, Maletta Raffaele, Bruni Amalia C, Passarino Giuseppe, Rose Giuseppina

Abstract excerpt

Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders, including Alzheimer's disease. A prominent feature of Alzheimer's disease is in fact neuronal glucose hypometabolism. Thus understanding the fine control of energetic...

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PMID: 27345265
DOI: 10.1016/j.bbadis.2016.06.014

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