Article
LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
PloS one - 1 Jan 2013
Lincoln Sarah, Allen Mariet, Cox Claire L, Walker Louise P, Malphrus Kimberly, Qiu Yushi, Nguyen Thuy, Rowley Christopher, Kouri Naomi, Crook Julia, Pankratz V Shane, Younkin Samuel, Younkin Linda, Carrasquillo Minerva, Zou Fanggeng, Abdul-Hay Samer O, Springer Wolfdieter, Sando Sigrid B, Aasly Jan O, Barcikowska Maria, Wszolek Zbigniew K, Lewis Jada M, Dickson Dennis, Graff-Radford Neill R, Petersen Ronald C, Eckman Elizabeth, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer's disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was previously shown to decrease secreted Aβ, although the mechanism of this is unclear. In SH-SY5Y cells overexpressing APP and...
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