Article
Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes.
The journals of gerontology. Series A, Biological sciences and medical sciences - 30 Apr 2021
Torres Guillermo G, Nygaard Marianne, Caliebe Amke, Blanché Hélène, Chantalat Sophie, Galan Pilar, Lieb Wolfgang, Christiansen Lene, Deleuze Jean-François, Christensen Kaare, Strauch Konstantin, Müller-Nurasyid Martina, Peters Annette, Nöthen Markus M, Hoffmann Per, Flachsbart Friederike, Schreiber Stefan, Ellinghaus David, Franke Andre, Dose Janina, Nebel Almut
Abstract excerpt
Despite enormous research efforts, the genetic component of longevity has remained largely elusive. The investigation of common variants, mainly located in intronic or regulatory regions, has yielded only little new information on the heritability of the phenotype. Here, we performed a chip-based exome-wide association study investigating 62 488 common and rare coding variants in 1248 German long-lived...
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