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Article

APOE and MS4A6A interact with GnRH signaling in Alzheimer's disease: Enrichment of epistatic effects.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2017

Cáceres Alejandro, Vargas José E, González Juan R

Abstract excerpt

INTRODUCTION: It is unknown if risk loci, identified by genome-wide association studies of late-onset Alzheimer's disease (LOAD), are linked to common molecular mechanisms through epistatic effects. METHODS: We performed genome-wide interaction studies of five risk variants for LOAD followed by enrichment analyses to find if there are pathways that simultaneously interact with more than one variant. This novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27337227
DOI: 10.1016/j.jalz.2016.05.009

Genes

APOE

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