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Article

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype.

Frontiers in immunology - 1 Jan 2020

Kressler Christopher, Gasparoni Gilles, Nordström Karl, Hamo Dania, Salhab Abdulrahman, Dimitropoulos Christoforos, Tierling Sascha, Reinke Petra, Volk Hans-Dieter, Walter Jörn, Hamann Alf, Polansky Julia K

Abstract excerpt

CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and promising effector cells for immuno-suppressive adoptive cellular therapy to fight autoimmunity and chronic inflammation. Their functional stability is critical for their clinical utility and has been correlated to the demethylated state of the TSDR/CNS2 enhancer element in the Treg lineage transcription factor FOXP3. However, proof...

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Identifiers

PMID: 33488615
DOI: 10.3389/fimmu.2020.609891
PMCID: PMC7817622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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