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DNA demethylation in the human <i>FOXP3</i> locus discriminates regulatory T cells from activated FOXP3<sup>+</sup> conventional T cells

13 Aug 2007

Abstract excerpt

The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg). Their number and functioning appears to be crucial in the prevention of autoimmunity and allergy, but also to be a negative prognostic marker for various solid tumors. Although expression of the transcription factor FOXP3 currently constitutes the best-known marker for Treg, in humans, transient expression is...

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PMID: 17694575
DOI: 10.1002/eji.200737594

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