Article
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.
Molecular psychiatry - 1 Jun 2021
Clements Caitlin C, Karlsson Robert, Lu Yi, Juréus Anders, Rück Christian, Andersson Evelyn, Boberg Julia, Pedersen Nancy L, Bulik Cynthia M, Nordenskjöld Axel, Pålsson Erik, Sullivan Patrick F, Landén Mikael
Abstract excerpt
Although large genome-wide association studies (GWAS) of major depressive disorder (MDD) have identified many significant loci, the SNP-based heritability remains notably low, which might be due to etiological heterogeneity in existing samples. Here, we test the utility of targeting the severe end of the MDD spectrum through genome-wide SNP genotyping of 2725 cases who received electroconvulsive therapy (ECT) for...
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