Article
The genetics of severe depression.
Molecular psychiatry - 1 Mar 2025
Franklin Clio E, Achtyes Eric, Altinay Murat, Bailey Kala, Bhati Mahendra T, Carr Brent R, Conroy Susan K, Husain Mustafa M, Khurshid Khurshid A, Lencz Todd, McDonald William M, Mickey Brian J, Murrough James, Nestor Sean, Nickl-Jockschat Thomas, Nikayin Sina, Reeves Kevin, Reti Irving M, Selek Salih, Sanacora Gerard, Trapp Nicholas T, Viswanath Biju, Wright Jesse H, Sullivan Patrick, Zandi Peter P, Potash James B
Abstract excerpt
Genome-wide association studies (GWASs) of major depressive disorder (MDD) have recently achieved extremely large sample sizes and yielded substantial numbers of genome-wide significant loci. Because of the approach to ascertainment and assessment in many of these studies, some of these loci appear to be associated with dysphoria rather than with MDD, potentially decreasing the clinical relevance of the findings....
Read the complete abstract on PubMedTopics
- Humans
- Genome-Wide Association Study
- Major Depressive Disorder
- Polymorphism, Single Nucleotide