Article
Exome-wide screening identifies novel rare risk variants for major depression disorder.
Molecular psychiatry - 1 Jul 2022
Cheng Shiqiang, Cheng Bolun, Liu Li, Yang Xuena, Meng Peilin, Yao Yao, Pan Chuyu, Zhang Jingxi, Li Chun'e, Zhang Huijie, Chen Yujing, Zhang Zhen, Wen Yan, Jia Yumeng, Zhang Feng
Abstract excerpt
Despite thousands of common genetic loci of major depression disorders (MDD) have been identified by GWAS to date, a large proportion of genetic variation predisposing to MDD remains unaccounted for. By utilizing the newly released UK Biobank 200,643 exome dataset, we conducted an exome-wide association study to identify rare risk variants contributing to MDD. After quality control, 120,033 participants with MDD...
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