Article

Investigating Genetic Heterogeneity in Major Depression Through Item-level Genetic Analyses of the PHQ-9

2019-01-23

Abstract excerpt

<h4>Background</h4> Major Depressive Disorder (MDD) is a clinically heterogeneous disorder. Previous large-scale genetic studies of MDD have explored genetic risk factors of MDD case-control status or aggregated sums of depressive symptoms, ignoring possible clinical or genetic heterogeneity. <h4>Aim</h4> In this study, we present the results of symptom-level genetic analyses and compare SNP-based heritability (...

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Literature Corpus work: 402aa18e-d423-5ede-b4db-6414df7c80ce
DOI: 10.1101/528067

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