Article
The Genetic Architecture of Major Depressive Disorder in Han Chinese Women.
JAMA psychiatry - 1 Feb 2017
Peterson Roseann E, Cai Na, Bigdeli Tim B, Li Yihan, Reimers Mark, Nikulova Anna, Webb Bradley T, Bacanu Silviu-Alin, Riley Brien P, Flint Jonathan, Kendler Kenneth S
Abstract excerpt
Importance: Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution of classes of genetic variation across the genome to inform future genetic studies of MDD. Objectives: To apply aggregate genetic risk...
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