An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease.

doi:10.1038/s41467-020-20750-8

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Article

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease.

Nature communications - 22 Jan 2021

Cohain Ariella T, Barrington William T, Jordan Daniel M, Beckmann Noam D, Argmann Carmen A, Houten Sander M, Charney Alexander W, Ermel Raili, Sukhavasi Katyayani, Franzen Oscar, Koplev Simon, Whatling Carl, Belbin Gillian M, Yang Jialiang, Hao Ke, Kenny Eimear E, Tu Zhidong, Zhu Jun, Gan Li-Ming, Do Ron, Giannarelli Chiara, Kovacic Jason C, Ruusalepp Arno, Lusis Aldons J, Bjorkegren Johan L M, Schadt Eric E

Abstract excerpt

Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by constructing network models from the STARNET study with sequencing data from seven cardiometabolic...

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PMID: 33483510
DOI: 10.1038/s41467-020-20750-8
PMCID: PMC7822923

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