Article
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.
PLoS genetics - 1 Jul 2014
Mäkinen Ville-Petteri, Civelek Mete, Meng Qingying, Zhang Bin, Zhu Jun, Levian Candace, Huan Tianxiao, Segrè Ayellet V, Ghosh Sujoy, Vivar Juan, Nikpay Majid, Stewart Alexandre F R, Nelson Christopher P, Willenborg Christina, Erdmann Jeanette, Blakenberg Stefan, O'Donnell Christopher J, März Winfried, Laaksonen Reijo, Epstein Stephen E, Kathiresan Sekar, Shah Svati H, Hazen Stanley L, Reilly Muredach P, Lusis Aldons J, Samani Nilesh J, Schunkert Heribert, Quertermous Thomas, McPherson Ruth, Yang Xia, Assimes Themistocles L
Abstract excerpt
The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite recent successes of genome-wide association studies (GWAS) in identifying novel susceptibility loci. Integrating functional genomic data from a variety of sources with a large-scale meta-analysis of CAD GWAS may facilitate the identification of novel biological processes and genes involved in CAD, as well as clarify the...
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