Article
Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease.
Molecular systems biology - 1 Jun 2025
Foguet Carles, Jiang Xilin, Ritchie Scott C, Persyn Elodie, Xu Yu, Ben-Eghan Chief, Taylor Henry J, Di Angelantonio Emanuele, Danesh John, Butterworth Adam S, Lambert Samuel A, Inouye Michael
Abstract excerpt
Genome-wide association studies have identified thousands of variants associated with disease risk but the mechanism by which such variants contribute to disease remains largely unknown. Indeed, a major challenge is that variants do not act in isolation but rather in the framework of highly complex biological networks, such as the human metabolic network, which can amplify or buffer the effect of specific risk...
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