Article
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets.
Scientific reports - 21 Feb 2018
Lempiäinen Harri, Brænne Ingrid, Michoel Tom, Tragante Vinicius, Vilne Baiba, Webb Tom R, Kyriakou Theodosios, Eichner Johannes, Zeng Lingyao, Willenborg Christina, Franzen Oscar, Ruusalepp Arno, Goel Anuj, van der Laan Sander W, Biegert Claudia, Hamby Stephen, Talukdar Husain A, Foroughi Asl Hassan, Pasterkamp Gerard, Watkins Hugh, Samani Nilesh J, Wittenberger Timo, Erdmann Jeanette, Schunkert Heribert, Asselbergs Folkert W, Björkegren Johan L M
Abstract excerpt
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to improve our understanding of CAD pathophysiology and identify potential therapeutic targets. Here, we prioritized 68 genes as the most likely causal genes at genome-wide significant...
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