Article
Single-cell transcriptional changes of artemisinin-sensitive K13C580 and artemisinin-resistant K13580Y Plasmodium falciparum upon dihydroartemisinin exposure.
Frontiers in cellular and infection microbiology - 1 Jan 2026
Connelly Sean V, Cunningham Clark, Petrow Ian, Rustamzade Nazrin, Zuromski Jenna, Sipolski Deborah M, Nixon Christian P, Kurtis Jonathan D, Juliano Jonathan J, Bailey Jeffrey A, Oduor Cliff I
Abstract excerpt
Artemisinin-based therapies have been central to malaria control, but partial resistance in Plasmodium falciparum, driven by mutations in the Kelch13 (K13) protein, threatens these gains. To investigate the molecular basis of this resistance, we applied single-cell RNA sequencing to isogenic parasite lines, K13 wild-type (K13C580) and the artemisinin-resistant mutant (K13580Y), following a 6h pulse of...
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