Article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
PLoS pathogens - 1 Apr 2020
Gnädig Nina F, Stokes Barbara H, Edwards Rachel L, Kalantarov Gavreel F, Heimsch Kim C, Kuderjavy Michal, Crane Audrey, Lee Marcus C S, Straimer Judith, Becker Katja, Trakht Ilya N, Odom John Audrey R, Mok Sachel, Fidock David A
Abstract excerpt
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with first-line ART-based combination therapies in Southeast Asia. Decreased parasite susceptibility is caused by K13 mutations, which are associated clinically with delayed parasite clearance in patients and in vitro with an enhanced ability of ring-stage parasites to...
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