Article
Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.
PLoS biology - 1 Apr 2015
Dogovski Con, Xie Stanley C, Burgio Gaetan, Bridgford Jess, Mok Sachel, McCaw James M, Chotivanich Kesinee, Kenny Shannon, Gnädig Nina, Straimer Judith, Bozdech Zbynek, Fidock David A, Simpson Julie A, Dondorp Arjen M, Foote Simon, Klonis Nectarios, Tilley Leann
Abstract excerpt
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutations in the K13 propeller protein. We undertook a detailed kinetic analysis of the drug responses of K13 wild-type and...
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