Article
The many paths to artemisinin resistance in Plasmodium falciparum.
Trends in parasitology - 1 Dec 2023
Pandit Kushankur, Surolia Namita, Bhattacharjee Souvik, Karmodiya Krishanpal
Abstract excerpt
Emerging resistance against artemisinin (ART) poses a major challenge in controlling malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are known to reduce hemoglobin endocytosis, induce unfolded protein response (UPR), elevate phosphatidylinositol-3-phosphate (PI3P) levels, and stimulate autophagy. Nonetheless, PfKelch13-independent resistance is also reported, indicating...
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