Article
Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.
PloS one - 1 Jan 2013
Nguyen Hai Dang, Becker Jordan, Thu Yee Mon, Costanzo Michael, Koch Elizabeth N, Smith Stephanie, Myung Kyungjae, Myers Chad L, Boone Charles, Bielinsky Anja-Katrin
Abstract excerpt
Deficiency in DNA ligase I, encoded by CDC9 in budding yeast, leads to the accumulation of unligated Okazaki fragments and triggers PCNA ubiquitination at a non-canonical lysine residue. This signal is crucial to activate the S phase checkpoint, which promotes cell cycle delay. We report here that a pol30-K107 mutation alleviated cell cycle delay in cdc9 mutants, consistent with the idea that the modification of...
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